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KMID : 1137820100310020134
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의공학회지
2010 Volume.31 No. 2 p.134 ~ p.140
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A Novel Method of Shape Quantification using Multidimensional Scaling
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Park Hyun-Jin
Yoon Uei-Joong
Seo Jong-Bum
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Abstract
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Readily available high resolution brain MRI scans allow detailed visualization of the brain structures. Researchers have focused on developing methods to quantify shape differences specific to diseased scans. We have developed a novel method to quantify shape information for a specific population based on Multidimensional scaling(MDS). MDS is a well known tool in statistics and here we apply this classical tool to quantify shape change. Distance measures are required in MDS which are computed from pair-wise image registrations of the training set. Registration step establishes spatial correspondence among scans so that they can be compared in the same spatial framework. One benefit of our method is that it is quite robust to errors in registrations. Applying our method to 13 brain MRI showed clear separation between normal and diseased (Cushing’s syndrome). Intentionally perturbing the image registration results did not significantly affect the separability of two clusters. We have developed a novel method to quantify shape based on MDS, which is robust to image mis-registration.
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KEYWORD
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shape, multidimensional scaling, image registration, DBM, VBM
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